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I've had my Sansa e260 for about four months, now. I'm very pleased with this product. The Sansa is very easy to use, its features work perfectly, and it looks and feels really nice.
You can sync the Sansa either with a software service (I've been successful with Rhapsody, Windows Media Player, and Napster), or using a simple windows folder interface. Each works perfectly, and all the music files will be usable inside the Sansa interface. The transfers are quite fast, and judging by the amount of space I've used, this model has room for several hundreds songs. I've also downloaded podcasts and loaded them up using the folder interface. They play fine, and simply show up on the master music list under their file name. There's also a media converter for photos and video, but I have not used those features.
The screen is very sharp and aids usability with a well-designed interface. The wheel and buttons on the front did take some getting used to, but now that I've been using it for a while, it seems second nature. The Sansa comes with some simple ear buds, which I can't stand. The third party earphones I purchased sound fantastic. The unit also has an FM radio integrated into it; you can switch to this by rotating the command dial to find the FM Radio menu item. I don't use it much, but it picks up a variety of radio stations near my home and work very clearly. There's a voice recorder (a "memo thingy") in the unit, but I can't imagine when I'd use that...
The overall unit is light, and small, but not too small to handle if you have fat fingers like me. Best of all, this unit has worked 100% perfectly for me. I haven't had a single hitch, burp or failure with my Sansa.
The unit comes with a USB cord that serves double duty as a charger and file transfer medium. The first charge took a long time, but subsequent use hasn't run down the battery very fast, so charge time isn't a big deal for me. However, if you intend to use an mp3 player a LOT, then the USB charge cord might become bothersome for you. It doesn't come with a very useful case, but I bought a very nice case for about ten bucks. Be careful not to buy a case that interferes with the use of the command dial or buttons. I also picked up an aftermarket retractable USB travel cord, which works fine.
I looked at several different players, including Apple, before deciding on the Sansa. I'm convinced I made the right call, and I couldn't be happier with the performance of this unit. I'd recommend it unconditionally to anyone who wants a reliable unit with good features and a reasonable price.