I literally picked up one of these things two weeks ago, and it's working fantastically.
I am running windows 8, using windows media center (I got WMC for free for buying windows 8 super early or something), anyways the set up didn't take too long, maybe a half an hour total.
Note: in order to decrypt channels this requires a cablecard from your provider. The cable card is called the "M-Card" (Comcast referred to it as a "Dual Card". It's pink, and motorola branded.
Set up with Comcast wasn't too bad, I used this post to give me the proper phone numbers to call when I had to call comcast. Those phone numbers actually get you to the correct department on the first try, where they ACTUALLY know what a cablecard is (I know, I was shocked too). Just note, that Comcast charges this to your bill as a cable box, and allows you to replace a cable box with it. So if your cable includes one box, this can be that box, but if you have another one too it will cost you $10 a month.
Anyways, after the activation process I got windows media center setup in a jiffy, and all was right with the world. Also, for some reason I get HD channels (I don't pay for upgraded HD... so go figure) through the Prime. I've been using my xbox360 as a windows media extender. The whole setup is working wonderfully.
There is also a "HomeRunTV" android app. Basically, it allows you to see the tuners on the network and switch to them on android. It requires another media player to work (I forget which two it said it's compatible with off the top of my head, but both of them were free.) The android streaming works... but it's not pretty. I'd imagine these are on woot because as someone said earlier they're coming out with a more mobile friendly version.
The one drawback I'd say this thing has is that it puts a lot of strain on your network. I run a standard 10/100 network and if I want to use all three turners at once on HD channels, it has network issues. If you have gigibit you should be fine. This might be a drawback to the "Wife Acceptance Factor", but it finally gives me an excuse to update to a gigabit router.